pentobarbital will lessen the level or outcome of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will lessen the extent or impact of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Reasonable CYP3A4 inducers could reduce progestin concentra